Author/Editor		Gažić, M
Title		Obiteljska studija seronegativnih spondilartritisa
Translated title		Family study of seronegative spondylarthritides
Type		članek
Source		Reumatizam
Vol. and No.		Letnik 36, št. 1-6
Publication year		1989
Volume		str. 35-40
Language		cro
Abstract		Genetic analysis of antigene HLA-B27 was performed in 11 families with seronegative spondylarthritides (SSA). 107 family members were examined. In all of them determination of antigene HLA-B27 was done, and all the patients, as well as the family members who anamnestically had any rheumatic troubles, were checked completely. The analysis showed strong linkage between antigene HLA-B27 and the disease. Of 30 affected persons, 26 (87 per cent) were HLA-B27 positive. The linkage has been mostly expressed in patients with ankylosing spondilitis (AS), (15 persons) i.e. all the affected by AS were HLA-B27 positive. Of 34 brothers, 19 (55,8 per cent) were B27 positive, and of totally examined 35 children of the second generation, 15 (43 per cent) were postitive. Classical AS developed in 6 brothers (17,6 per cent) and all were B27 positive. Disease distribution in relation to sex has been 4:1 for classical AS in favour of men. This proportion has been reducing if taking into account incomplete types of disease, as well as HLA-B27 negative patients, amounting to 1,5:1 HLA-B27 negative patients, as well as incomplete types of disease have been found exclusively in women. In our female patients the disease began later, with milder clinical picture, and minor X-ray changes
Descriptors		SPONDYLITIS, ANKYLOSING RHEUMATOID FACTOR HLA-B27 ANTIGEN