Avtor/Urednik		Kern, Izidor; Kecelj, Peter; Košnik, Mitja; Mermolja, Milivoj
Naslov		Multinucleated giant cells in bronchoalveolar lavage
Tip		članek
Vir		Acta Cytol
Vol. in št.		Letnik 47, št. 3
Leto izdaje		2003
Obseg		str. 426-30
Jezik		eng
Abstrakt		Oobjective: To determine the frequency, morphology and possible diagnostic significance of multinucleated giant cells (MGC) in bron choalveolar lavage (BAL). Study design: Retrospectively we examined 671 BAL specimens. Enlarged cells having >= 10 nuclei were defined as MGC. Cytomorphologic features were described. BAL specimens containing MGC were grouped according to clinicohistologic diagnosis into sarcoidosis, asbestosis, other interstitial lung diseases and different chronic, noninterstitial lung diseases. Results: MGC were present in 10.7% of BAL specimens and occurred in low numbers. MGC were classified into Langhans' or foreign-body-type MGC (LF-MGC), alveolar macrophage-like MGC (AM-MGC) and nonspecific MGC (NS-MGC). LF-MGC were found most often in patients with sarcoidosis. AM-MGC were found in all groups of patients. NS-MGC were found most often in patients with asbestosis and other interstitial lung diseases. Conclusion: MCG in BAL are not encountered frequently and are not numerous. Based on cytomorphologic features, three types of MGC can be distinguished.
Deskriptorji		ASBESTOSIS BRONCHOALVEOLAR LAVAGE GIANT CELLS SARCOIDOSIS BRONCHOALVEOLAR LAVAGE FLUID CELL COUNT GIANT CELLS, FOREIGN-BODY GIANT CELLS, LANGHANS MACROPHAGES, ALVEOLAR RETROSPECTIVE STUDIES