Avtor/Urednik		Grach-Pogrebinsky, Olga; Sedmak, Bojan; Carmeli, Shmuel
Naslov		Protease inhibitors from a Slovenian lake Bled toxic waterbloom of the cyanobacterium Planktothrix rubescens
Tip		članek
Vir		Tetrahedron
Vol. in št.		Letnik 59
Leto izdaje		2003
Obseg		str. 8329-36
Jezik		eng
Abstrakt		Three new protease inhibitors, planktopeptin BL 1125, planktopeptin BL843 and planktopeptin BL 1061 were isolated, along with three known compounds, anabaenopeptin A, anabaenopeptin B and anabaenopeptin F from the hydrophilic extract of Planktothrix rubescens. The planar structure of the new compounds was determined by homonuclear and inverse-heteronuclear 2D NMR techniques as well as highresolution mass spectrometry. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC and by comparison of the acid hydrolysate with authentic samples on a chiral HPLC column. The new peptides were found to be elastase and chymotrypsin inhibitors.
Deskriptorji		FRESH WATER WATER POLLUTANTS EUTROPHICATION CYANOBACTERIA PROTEASE INHIBITORS SPECTRUM ANALYSIS, MASS CHROMATOGRAPHY, HIGH PRESSURE LIQUID