Author/Editor		Drevenšek, Petra; Golobič, Amalija; Turel, Iztok; Poklar, Nataša; Sepčić, Kristina
Title		Kristalna struktura in karakterizacija ionske spojine bakra(II) in ciprofloksacina
Type		članek
Source		In: Glavič P, Brodnjak-Vončina D, editors. Slovenski kemijski dnevi 2002. Zbornik referatov s posvetovanja. 2. del; 2002 sep 26-27; Maribor. Maribor: Univerza v Mariboru, Fakulteta za kemijo in kemijsko tehnologijo,
Publication year		2002
Volume		str. 802-7
Language		slo
Abstract		A new ionic compound, ciprolloxacinium(1+) ciprofloxacinium(2+) tetrachlorocuprate(lI) chloride hydrate, (cfH2)(cfH3)[CuCla]C1H20, 1, was isolated. X-ray crystallography shows no direct bonds between the quinolone and metal. Both ciprofloxacin (cfH = 1-cyclopropyl6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quin oline carboxylic acid) molecules are protonated thus being unable to coordinate to the copper. The new complex has been characterised by intrinsic fluorescence emission and UV spectroscopy. The title compound as well as two previously isolated copper complexes, [Cu(cfH)(H20)3]S042H20, 2 and [Cu(cfH)2]Cl2 6H20, 3, were tested against the growth of various Gram positive and Gram negative microorganisms. The binding of a new compound to DNA has also been tested by UV spectroscopy. Our results reveal that (cfH2)(cfH3)[CuCl4]ClH20 slightly thermally destabilise the linear double stranded DNA at pH 7.0.
Descriptors		COPPER CIPROFLOXACIN CRYSTALLOGRAPHY, X-RAY TECHNOLOGY, PHARMACEUTICAL X-RAY DIFFRACTION SPECTROMETRY, FLUORESCENCE MICROBIAL SENSITIVITY TESTS