Author/Editor		Beović, Bojana
Title		Novi fluorokinoloni: levofloksacin, moksifloksacin, gatifloksacin, gemifloksacin
Translated title		New fluoroquinolones: levofloxacin, moxifloxacin, gatifloxacin, gemifloxacin
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 2
Publication year		2004
Volume		str. 69-81
Language		slo
Abstract		In the last decade new quinolone antibiotics with better activity against penumococci were developed primarily for the treatment of respiratory tract infections. In Slovenia levofloxacin and moxifloxacin are on the market, gatifloxacin and gemifloxacin are available in addition in other parts of the world. Numerous studies proved their clinical efficacy, in some studies their efficacy is superior to the standard antibiotics for the same indications. Safety was confirmed in clinical studies and in postmarketing period. Pharmacokinetic properties allow easy administration and sequential treatment. In vitro results and some clinical data suggest relatively slow development of bacterial resistance against new quinolones. In a review article clinical pharmacology, efficacy and safety of levofloxacin, moxifloxacin, gatifloxacin and gemifloxacin are described.
Summary		V zadnjem desetletju so se kinolonskim kemoterapevtikom pridružila nova zdravila, ki so zaradi izboljšane učinkovitosti proti pnevmokokom primerna zlasti za zdravljenje okužb dihal. V Sloveniji sta na tržišču levofloksacin in moksifloksacin, po svetu sta v klinični uporabi še gatifloksacin in gemifloksacin. Številne raziskave so dokazale njihovo klinično učinkovitost, ki po nekaterih podatkih presega dosedanje načine zdravljenja. Varnost je bila potrjena tudi v postmarketinškem obdobju. Odlikuje jih farmakokinetika, ki omogoča enostavno odmerjanje in sekvenčno zdravljenje. Rezultati in vitro in delno klinične izkušnje dokazujejo, da je razvoj odpornosti proti novim kinolonom sorazmerno počasen. V preglednem prispevku so podrobneje opisane kliničnofarmakološke lastnosti, učinkovitost in varnost levofloksacina, moksifloksacina, gatifloksacina in gemifloksacina.
Descriptors		ANTI-INFECTIVE AGENTS, FLUOROQUINOLONE DRUG RESISTANCE, MICROBIAL MICROBIAL SENSITIVITY TESTS