Author/Editor		Vogrin, Bernarda; Vogrin, Matjaž; Miksić, Mirjana; Roškar, Zdravko; Šauperl, Mira
Title		Pomen določanja serumskih transferinskih receptorjev
Translated title		The role of serum transferrin receptors measurement
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 73, št. 4
Publication year		2004
Volume		str. 203-5
Language		slo
Abstract		Background. The transferrin receptors are transmembrane proteins. They have a critical role in iron metabolism by controlling the flow of transferrin iron into body cells. The density of a surface transferrin receptor on a given cell is proportional to the iron requirements of that cell. A soluble form of the receptor can be detected in human serum by sensitive immunoassays. Conclusions. Concentration of serum transferrin receptor reflects total erythropoietic activity of human body. It provides a quantitative measure of functional iron deficiency and distinguishes the associated anemia from that of chronic disease. Elevated serum receptor levels provide a valuable measure of enhanced erythropoiesis. It might be useful for measuring of the therapeutic effect of recombinant human erythropoetin. It is more sensitive and less invasive than bone marrow examination currently used to assess a red cell precursor mass.
Summary		Izhodišča. Transferinski receptorji so transmembranski proteini, ki imajo ključno vlogo v presnovi železa. Omogočajo transport na transferin vezanega železa v celice. Kadar je potreba po železu velika, celice pomnožijo transferinske receptorje. Koncentracija serumskih transferinskih receptorjev je sorazmerna koncentraciji membranskih receptorjev in odslikava celotno eritropoetsko dejavnost. Zaključki. Topne receptorje lahko določamo v serumu z imunološkimi preiskavami. Z merjenjem koncentracije transferinskih receptorjev v serumu lahko količnsko merimo stopnjo pomanjkanja železa in ločimo med anemijo zaradi kroničnih bolezni in anemijo zaradi pomanjkanja železa. Pri stanjih s pospešeno eritropoezo lahko spremljamo aktivnost bolezni. Primerni so za spremljanje zdravljenja s humanim eritropoetinom. So zelo občutljiv kazalec eritropoeze, pogosto lahko celo nadomestijo citološki pregled kostnega mozga. Različna fiziološka stanja (nosečnost) in vnetja ne vplivajo na koncentracijo serumskih transferinskih receptorjev.
Descriptors		ANEMIA ANEMIA, IRON-DEFICIENCY RECEPTORS, TRANSFERRIN IRON CHILD