Author/Editor		Petrič, Primož; Budihna, Marjan; Šmid, Lojze
Title		Rezultati zdravljenja karcinoma ustne votline z radikalnim ali pooperacijskem obsevanjem na Onkološkem inštitutu v Ljubljani
Translated title		Results of treatment of oral cavity carcinoma with radical or postopertaive radiotherapy at the Institute of oncology in Ljubljana
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 3
Publication year		2004
Volume		str. 283-7
Language		slo
Abstract		According to reports from literature, the results of radiotherapy for stage I and II oral cavity carcinoma are equal to those of surgical treatment. Patients with an advanced disease benefit most from a combination of surgery and irradiation. Two-hundred and thirty-five patients treated with curative intent at the Ljubljana Institute of Oncology between 1990 and 1995 were included in our retrospective study. Ninety-three patients were treated with irradiation with radical intent and 142 patients with postoperative irradiation. Regardless of the treatment approach, the results were better in patients with early primary tumours, clinically non-palpable nodes and early disease stages (p < 0.05). In patients with T1 or T2 tumours, local control after combined treatment was better than after irradiation (p < 0.05). On the other hand, in node-free patients and in patients with disease stages I or II, no statistically significant differences were detected between the two therapeutic approaches concerning regional disease control and survival (overall and disease-free), respectively. In patients with T3 or T4 tumours, involved neck lymph nodes or disease stages III or IV, the results of combined treatment were superior to those of irradiation with radical intent (p < 0.05).
Summary		Glede na poročila v literaturi so rezultati radikalnega obsevanja tumorjev ustne votline štadijev I in II enkovredni rezultatom kirurgije. Pri napredovali bolezni nudi boljšo možnost ozdravitve kombinacija operacije in obsevanja. V našo retrospektivno raziskavo smo vključili 235 bolnikov, zdravljenih z namenom ozdravitve na Onkološkem inštitutu v Ljubljani od leta 1990 do 1995. Z obsevanjem z radikalnim namenom je bilo zdravljenih 93, s pooperacijskim obsevanjem pa 142 bolnikov. Rezultati so bili ne glede na način zdravljenja boljši pri bolnikih z manjšimi primarnimi tumorji, klinično neprizadetimi bezgavkami in začetnimi bolezenskimi štadiji (p < 0,05). Pri bolnikih s T1- in T2-tumorji je bilo lokalno brez bolezni po kombiniranem zdravljenju več bolnikov kot samo po obsevanju (p < 0,05). Pri bolnikih z neprizadetimi bezgavkami oz. bolezenskimi štadiji I-II pa med obema načinoma zdravljenja ni bilo statistično značilnih razlik v regionalni ozdravitvi oz. celokupnem preživetju in preživetju brez bolezni. Pri bolnikih s T3- ali T4-tumorji, prizadetimi vratnimi bezgavkami oz. bolezenskimi štadiji III ali IV so bili rezultati kombiniranega zdravljenja statistično značilno boljši kot rezultati obsevanja z radikalnim namenom (p < 0,05).
Descriptors		MOUTH NEOPLASMS NEOPLASM STAGING SURVIVAL ANALYSIS DISEASE-FREE SURVIVAL RETROSPECTIVE STUDIES