Author/Editor		Letonja, Mitja; Gužič-Salobir, Barbara; Peterlin, Borut; Petrovič, Daniel
Title		Apolipoprotein E gene polymorphism effects triglycerides but not CAD risk in Caucasian women younger than 65 years
Type		članek
Source		Ann Genet
Vol. and No.		Letnik 47
Publication year		2004
Volume		str. 147-53
Language		eng
Abstract		The pathogenesis of CAD is similar in man and woman, yet some risk factors have a greater impact on the CAD risk in woman than in man. In this study we assessed the effect of the apoE gene polymorphism on lipid metabolism and risk for CAD in women younger than 65 years (premature CAD). In a cross-sectional case-control study, 147 female Caucasian patients with premature CAD (confirmed by coronarography) were compared with a control group of 114 healthy Caucasian women. The apoE allele frequencies of patients vs. controls were 5.1% vs. 5.7% for s2, 85.4% vs. 83.3%; for eta3, and 9.5% vs. (11% for eta4. The subjects with eta2/3 genotype had statistically significantly higher triglycerides levels than the subjects with eta3/3 genotype (2.23 ± 2.13 mml L-1 vs. 1.73 ± 0.84 mmol L-1; p < 0.05). Logistic regression analysis revealed no association between risk genotypes (s3/4 and s4/4) of the apoE gene polymorphism and CAD risk (OR 0.9; 95% CI 0.5-1.7, P=0.7). We observed metabolic clustering of diabetes mellitus, arterial hypertension, higher BMI and triglycerides, and lower HDL cholesterol in the CAD group compared to the control group. Arterial hypertension, diabetes, HDL cholesterol level, and BMl were independent risk factors for premature CAD in female population, whereas, the risk genotype of the apoE gene polymorphism was not. In conclusion, in Slovene women risk genotypes of the apoE gene polymorphism are not associated with premature CAD; a metabolic clustering of diabetes, HDL, triglycerides and arterial hypertension is frequently present in Caucasian women with premature CAD.
Descriptors		CORONARY DISEASE APOLIPOPROTEINS E TRIGLYCERIDES GENOTYPE CORONARY ANGIOGRAPHY POLYMERASE CHAIN REACTION LIPOPROTEINS, HDL CHOLESTEROL ALLELES HYPERTENSION DIABETES MELLITUS SMOKING BODY MASS INDEX CROSS-SECTIONAL STUDIES