Author/Editor		Look, Maxime; van Putten, Vim; Duffy, Michael; Harbeck, Nadia; Christensen, Ib Jarle; Thomssen, Christoph; Kates, Ronald; Spyratos, Frederique; Čufer, Tanja; Borštnar, Simona
Title		Pooled analysis of prognostic impact of uPA and PAI-I in breast cancer patients
Type		članek
Source		Thromb Haemost
Vol. and No.		Letnik 90
Publication year		2003
Volume		str. 538-48
Language		eng
Abstract		In this report we present an extension of the pooled analysis of the prognostic impact of urokinase-type plasminogen acdvator (uPA) and its inhibitor PA!-I in breast rancer patients. We analyzed a different endpoint, metastasis-free survival (MFS). We checked the consistency of the estimates for uPA and PAI-I for relapse-free survival (RFS) and MFS exploring possible sources of heterogeneity. Nodal status, the most important prognostic factor for breast cancer, introduced heterogeneity in the uPAIPAI-I survival analyses, reflecting the interaction between nodal status and uPAIPAI-I.The estimates for uPA and PAI-I were found to be consistent, even when a different transforma- , tion of their values was used. The heterogeneity of the separate data sets decreased if the levels of uPA and PAI-I were ranked, data sets were pooled, and the analyses corrected for the base model that included all traditional prognostic factors, and stratified by data set. We conclude that uPA and PAI-I are ready to be used in the clinic to help classify breast cancer patients into high and low risk groups.
Descriptors		BREAST NEOPLASMS PLASMINOGEN ACTIVATOR INHIBITOR 1 UROKINASE DISEASE-FREE SURVIVAL LYMPH NODES MULTIVARIATE ANALYSIS NEOPLASM METASTASIS PREDICTIVE VALUE OF TESTS PROGNOSIS