Avtor/Urednik		Bilalović, Nurija; Blystad, AnneKristi; Golouh, Rastko; Nesland, Jahn M; Selak, Ivan; Trinh, Don; Torlaković, Emina
Naslov		Expresion of blc-6 and CD10 protein is associated with longer overall survival and time to treatment failure in follicular lymphoma
Tip		članek
Vir		Am J Clin Pathol
Vol. in št.		Letnik 121, št. 1
Leto izdaje		2004
Obseg		str. 34-42
Jezik		eng
Abstrakt		Follicular lymphomas (FLs) are a heterogeneous group of tumors, but prognostic factors are evaluated insufficiently in this common hematologic neoplasm. While bcl-6 and CD10 are expressed characteristically in FLs, their significance for biologic behavior of FL has not been studied previously. Samples from 73 patients with FL and clinical follow-up from 7 to 231 months were evaluated by immunohistochemical analysis. Patients with high levels of bcl-G expression had favorable overall survival (OS) (P = .003), disease-specific survival (DSS) (P= .033), and time to treatment failure (P= .003) compared with patients with low levels of bcl-6 expression. Multivariate analysis showed that the results for OS, DSS, and time to treatment failure were independent of the international prognostic index. Patients with CD10+ FLs also had longer OS (P= .001), DSS (P = .007), and time to treatment failure (P = .004), and grade 1 FL was associated with better OS (P= .01) and a statistical trend for longer DSS (P = .05) and time to treatment failure (P = .05), but these results were not independent of bcl-6 expression or the international prognostic index in multivariate analysis.
Deskriptorji		TRANSCRIPTION FACTORS PROTO-ONCOGENE PROTEINS NEPRILYSIN DNA-BINDING PROTEINS LYMPHOMA, FOLLICULAR AGE FACTORS SEX FACTORS TREATMENT FAILURE TUMOR MARKERS, BIOLOGICAL SURVIVAL ANALYSIS NEOPLASM STAGING FOLLOW-UP STUDIES DISEASE-FREE SURVIVAL IMMUNOENZYME TECHNIQUES