Author/Editor		Kveder, M; Pečar, S; Nemec, M; Schara, M
Title		Nitroxide radicals as a model system for biotransformations of radicals in tissues
Type		članek
Source		Acta Pharm Jugosl
Vol. and No.		Letnik 41, št. 4
Publication year		1991
Volume		str. 391-400
Language		eng
Abstract		Nitroxide free radicals were used as a model system to study the biotransformation of free radicals in rat liver tissue samples. The results indicate that in aerobic conditions iron ions can switch the commonly observed reduction of nitroxides into the prevalence of re-oxidation proccsses. These observations were confirmed by the experiments in aqueous solutions with homogeneous mixtures of reactants. The conclusions from this study confirm the general idea of oxygen toxicity and give an insight in the possible mechanisms sustaining radical vitality in vivo in the presence of iron ions or their complexes.
Descriptors		NITROUS OXIDE BIOTRANSFORMATION LIVER ELECTRON SPIN RESONANCE IRON ASCORBIC ACID