Avtor/Urednik		Obreza, A; Stegnar, M; Trampuž-Bakija, A; Preželj, A; Urleb, U
Naslov		Synthesis and in vitro evaluation of new azaphenylalanine derivatives as serine protease inhibitors
Tip		članek
Vir		Pharmazie
Vol. in št.		Letnik 59
Leto izdaje		2004
Obseg		str. 739-43
Jezik		eng
Abstrakt		New inhibitors of serine proteases with azaphenylaianine scaffold were synthesized and their activity was evaluated in vitro. We studied the effect of different substituents in the part of a molecule that binds in the distal pocket of the thrombin active site. Modifications generally led to decreased activity, however two derivatives are promising lead compounds as new thrombin and dual thrombin-factor Xa inhibitors.
Deskriptorji		DRUG APPROVAL TECHNOLOGY, PHARMACEUTICAL DRUG INDUSTRY SERINE PROTEINASE INHIBITORS AZA COMPOUNDS PHENYLALANINE THROMBIN BINDING SITES FACTOR XA