Author/Editor | Mencinger, M; Panagopoulos, I; Contreras, JA; Mitelman, F; Aman, P | |
Title | Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines | |
Type | članek | |
Source | Biochim Biophys Acta | |
Vol. and No. | Letnik 1395, št. 2 | |
Publication year | 1998 | |
Volume | str. 176-80 | |
Language | eng | |
Abstract | Clone 120041 was selected from the EST database for sequence similarity to DEK and SET proteins rearranged in leukemias. The ends of the cDNA were isolated by RACE technique. The assembled cDNA encodes an LRR-containing protein of 251 amino acids designated APRIL (acidic protein rich in leucines). APRIL has high similarity to human pp32, also named PHAPI (bovine I[PP2A]1), and to rat LANP, respectively. APRIL shows tissue-specific expression as shown by Northern blot analysis. It was localized to 15q25 by FISH. | |
Descriptors | CHROMOSOMES, HUMAN, PAIR 15 NEUROPEPTIDES NUCLEAR PROTEINS AMINO ACID SEQUENCE BASE SEQUENCE BINDING SITES CHROMOSOME MAPPING CYCLIC AMP-DEPENDENT PROTEIN KINASES GENE EXPRESSION MOLECULAR SEQUENCE DATA PHOSPHORYLATION PROTEIN-SERINE-THREONINE KINASES RATS TUMOR CELLS, CULTURED |