Author/Editor     Mencinger, M; Panagopoulos, I; Contreras, JA; Mitelman, F; Aman, P
Title     Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines
Type     članek
Source     Biochim Biophys Acta
Vol. and No.     Letnik 1395, št. 2
Publication year     1998
Volume     str. 176-80
Language     eng
Abstract     Clone 120041 was selected from the EST database for sequence similarity to DEK and SET proteins rearranged in leukemias. The ends of the cDNA were isolated by RACE technique. The assembled cDNA encodes an LRR-containing protein of 251 amino acids designated APRIL (acidic protein rich in leucines). APRIL has high similarity to human pp32, also named PHAPI (bovine I[PP2A]1), and to rat LANP, respectively. APRIL shows tissue-specific expression as shown by Northern blot analysis. It was localized to 15q25 by FISH.
Descriptors     CHROMOSOMES, HUMAN, PAIR 15
NEUROPEPTIDES
NUCLEAR PROTEINS
AMINO ACID SEQUENCE
BASE SEQUENCE
BINDING SITES
CHROMOSOME MAPPING
CYCLIC AMP-DEPENDENT PROTEIN KINASES
GENE EXPRESSION
MOLECULAR SEQUENCE DATA
PHOSPHORYLATION
PROTEIN-SERINE-THREONINE KINASES
RATS
TUMOR CELLS, CULTURED