Author/Editor		Eržen, Janez; Vidmar, Stanko; Sok, Miha; Debeljak, Andrej; Kecelj, Peter; Kovač, Viljem; Stanovnik, Marjeta; Rott, Tomaž; Kern, Izidor
Title		Surgical treatment of malignant pleural mesothelioma. Experience in the interdisciplinary approach in Slovenia
Translated title		Kirurško zdravljenje malignega plevralnega mezotelioma. Izkušnje interdisciplinarne obravnave v Sloveniji
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 39, št. 2
Publication year		2005
Volume		str. 123-31
Language		eng
Abstract		Background. The aim of the study was to identify perioperative morbidity and mortality, the category and mode of adjuvant treatment, local recurrence and survival in patients treated by extrapleural pneumonectony (EPP) for malignant pleural mesothelioma (NLPM). Methods. From 2000 to 2003, 18 patients with MPM were referred to the Department of Thoracic Surgery in Ljubljana, and 17 of them were operated on. Two patients underwent explorative thoracotomy, and 15 patients were evaluated. Five female and nine male patients (aged 52-68 years) were treated by EPP and one male patient by pleurectomy. Eight patients received both adjuvant chemotherapy (ChT) and radiotherapy (RT), with cisplatin 100 mg/m2 + mitomycin C 6-10 mg/m2 gemcitabine 1000 mg/m2 and external beam radiation with 24 Gy - 58 Gy respectively, three patients received no adjuvant therapy, three patients were treated by adjuvant ChT, two of them were given cisplatin 100 mg/m2 + mitomycin C 6-10 mg/m2, and one patient cisplatin 100 mg/m2 on the first day and gemcitabine 250 mg/rn2 in prolonged 6 hours infusion on the first and on the eighth day. One patient was treated only by adjuvant RT. Results. There were no perioperative deaths and the postoperative morbidity was 42%. Of the 15 evaluable patients, and in the median follow up of 40 months (28-64), we noticed nine (60.0%) recurrences, seven local and two abdominal. Eight (53.3%) patients died, all because of the local progress of disease. (Abstract truncated at 2000 characters)
Summary		Izhodišča. Namen raziskave je bil ugotoviti operacijske zaplete, pooperacijsko smrtnost, vrsto in načine dopolnilnega zdravljenja, potek bolezni in preživetje pri bolnikih, pri katerih je bila narejena ekstraplevralna pnevmonektomija (EPP) ali plevrektomija zaradi malignega plevralnega mezotelioma (MPM). Metode. V letih od 2000 do 2003 je bilo 18 bolnikov z MPM napotenih na Klinični oddelek za torakalno kirurgijo Kliničnega centra v Ljubljani. Operirali smo 17 bolnikov in pri dveh naredili samo eksplorativno torakotomijo, preostalih 15 pa smo operirali z namenom ozdravitve. Pri 5 ženskah in 9 moških (starih od 52 do 68 let) smo naredili EPP, pri enem pa plevrektomijo. Osem bolnikov je po operaciji dobivalo cisplatin 100 mg/m2 + mitomicin C 6-10 mg/m2 (5 bolnikov) ali gemcitabin 1000 mg/m2(3 bolniki) in imelo obsevanje hemitoraksa od 24 Gy do 58 Gy (KT+RT); 3 niso bili dodatno zdravljeni; 3 so prejeli le citostatike brez obsevanja (KT) od tega sta 2 bolnika dobila cisplatin 100 mg/m2 + mitomicin C 6-10 mg7m2, eden pa cisplatin 100 mg/m2 in gemcitabin v podaljšani infuziji (250 mg/m2 1. in 8. dan); en bolnik je bil le obsevan (54 Gy). Rezultati. V zgodnjem pooperacijskem obdobju ni nihče umrl, pooperativnih zapletov pa je bilo 42%. V srednjem opazovalnem obdobju 40 mesecev (28-64) smo pri 9 do 5 (60%) bolnikih ugotovili ponovitev bolezni, 8 od 15 (53,3%) bolnikov je umrlo, vsi zaradi lokalne ponovitve tumorja.(Izvleček skrajšan na 2000 znakov)
Descriptors		PLEURAL NEOPLASMS MESOTHELIOMA NEOPLASM STAGING POSTOPERATIVE COMPLICATIONS SURVIVAL ANALYSIS