Avtor/Urednik		Angelova-Fischer, I; Tsankov, N
Naslov		Successful treatment of severe atopic dermatitis with cysteinyl leukotriene receptor antagonist montelukast*
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 14, št. 3
Leto izdaje		2005
Obseg		str. 115-9
Jezik		eng
Abstrakt		Leukotrienes are potent proinflammatory mediators derived from of arachidonic acid through the 5 lipoxygenase pathway. Experimental data suggest a role for cysteinyl leukotrienes in the pathogenesis of atopic dermatitis and there is a rationale for the use of pharmacological agents to antagonize their effects in the treatment of atopic dermatitis. We report 2 cases of severe atopic dermatitis successfully treated with montelukast as a single therapeutic agent in a daily dose of 10 mg for 8 weeks when corticosteroid treatment was contraindicated or failed to control the disease. Our observations suggest that montelukast may be used as an alternative steroid sparing medication for severe atopic dermatitis, especially in patients with associated asthma and rhinitis.
Deskriptorji		DERMATITIS, ATOPIC RECEPTORS, LEUKOTRIENE ADULT