Author/Editor		Večerić-Haler, Željka
Title		Vnetni odgovor črevesne sluznice in citokini pri Crohnovi bolezni
Translated title		Mucosal inflammatory response and cytokines in Crohn's disease
Type		članek
Source		Gastroenterolog
Vol. and No.		Letnik 9, št. 20
Publication year		2005
Volume		str. 10-5
Language		slo
Abstract		The primary function of the intestinal mucosal immune system is to protect against invasion by pathogenic micro-organisms. Recognition of pathogens by the intestinal mucosal system depends in part on the ability of intestinal mucosal cells do differentiate between pathogens and indigenous flora, and in part on the immunological tolerance that exist towards antigens that are derived from autologous intestinal bacteria. To prevent undue inflammatory responses and excessive tissue damage, the mucosal inflammatory response must be tightly controlled at multiple levels, and even in the case of bacterial invasion, the inflammatory response must eventually be shut down. lnflammatory responses are mainly orchestrated by cytokines that enable immune cells to communicate reciprocally, and to send signals to non-immune cells. Evidence has accumulated that ill-regulated mucosal immune responses may he central to the pathogenesis of inflammatory bowel diseases, and this has enabled the development of new therapeutic strategies.
Summary		Osnovna funkcija črevesnega imunskega sistema je zaščititi telo pred vdorom patogenih mikroorganizmov preko črevesne sluznice. Prepoznava patogenih mikrobov temelji predvsem na sposobnosti razlikovanja med lastno floro in patogenimi mikroorganizmi. Vnetni odgovor črevesne sluznice mora biti kontroliran natančno in na več nivojih, saj bi pretiran in neprimeren odgovor imunskega sistema lahko povzročil okvaro tkiva. Vsak imunski odziv poteka v medsebojnem sodelovanju raznovrstnih in številnih imunskih celic, ki se zbirajo na mestu vdora mikrobov ter z medsebojnim signaliziranjem usklajujejo svoje aktivnosti v primerno organiziran imunski odgovor. Za medsebojno signaliziranje uporabljajo imunske celice neposredne receptorske povezave predvsem preko adhezijskih molekul ter citokine-signalne molekule. lztirjen imunski odziv je glede na dosedanje raziskave osrednji patogenetski mehanizem Crohnove bolezni. Na podlagi novih spoznanj, pretežno iz področja imunologije, so se v zadnjih letih pojavila nova imunomodulatorna zdravila, ki že kažejo odlične uspehe pri zdravljenju najhujših oblik Crohnove bolezni.
Descriptors		CROHN DISEASE INFLAMMATION T-LYMPHOCYTES, HELPER-INDUCER CYTOKINES TUMOR NECROSIS FACTOR