Avtor/Urednik		Trampuš, Alenka
Naslov		Vpliv nikardipina in njegovih enantiomer na črevesno absorpcijo digoksina pri burdah in vivo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		1993
Obseg		str. 25
Jezik		slo
Abstrakt		Simultaneous administration of digoxin and calcium channel blockers results in an increased plasma level of digoxin. One of the possible mechanisms of this interaction could also be a changed enteral absorption of digoxin under the influence of calcium channel blockers. In the study of possible involvement of calcium channel blockers in the enteral absorption of digoxin it was shown that calcium channel blockers inhibited the intestinal absorption of digoxin. In further study of this interaction experiments with nicardipine and its (-) and (+) enantiomers in guinea pig in vivo were carried out. The intraveniously determined minimal lethal dose of digoxin 30 min after its intraduodenal administration was increased in animals pretreated with either (±)nicardipine or (-)nicardipine, but not after (+)nicardipine. These results indicate that the effectiveness of nicardipine in described interaction depends upon its optical activity.
Deskriptorji		NICARDIPINE INTESTINAL ABSORPTION DIGOXIN STEREOISOMERISM GUINEA PIGS