Author/Editor		Trampuš, Alenka
Title		Vpliv nikardipina in njegovih enantiomer na črevesno absorpcijo digoksina pri burdah in vivo
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		1993
Volume		str. 25
Language		slo
Abstract		Simultaneous administration of digoxin and calcium channel blockers results in an increased plasma level of digoxin. One of the possible mechanisms of this interaction could also be a changed enteral absorption of digoxin under the influence of calcium channel blockers. In the study of possible involvement of calcium channel blockers in the enteral absorption of digoxin it was shown that calcium channel blockers inhibited the intestinal absorption of digoxin. In further study of this interaction experiments with nicardipine and its (-) and (+) enantiomers in guinea pig in vivo were carried out. The intraveniously determined minimal lethal dose of digoxin 30 min after its intraduodenal administration was increased in animals pretreated with either (±)nicardipine or (-)nicardipine, but not after (+)nicardipine. These results indicate that the effectiveness of nicardipine in described interaction depends upon its optical activity.
Descriptors		NICARDIPINE INTESTINAL ABSORPTION DIGOXIN STEREOISOMERISM GUINEA PIGS