Avtor/Urednik     Ferk, Polonca; Geršak, Ksenija; Teran, Nataša
Naslov     No association between the microsatellite polymorphism (TTTTA)n in the promoter of the CYP11A gene and ovarian hyperstimulation syndrome
Tip     članek
Vir     J Assist Reprod Genet
Vol. in št.     Letnik 23, št. 1
Leto izdaje     2006
Obseg     str. 29-32
Jezik     eng
Abstrakt     Purpose: Women with ultrasonic evidence of polycystic ovaries are at higher risk of ovarian hyperstimulation syndrome (OHSS). We focused on investigating a possible association of the (TTTTA)n microsatellite polymorphism in the promoter of the CYP11A gene with OHSS during controlled ovarian hyperstimulation (COH). Methods: We evaluated 58 patients at high risk of OHSS (study group) and 58 control patients undergoing controlled ovarian hyperstimulation. Results: The difference in the allele distribution between both groups of patients was not statistically significant. The genotype distribution of 4+ (with at least one copy of the fourrepeat-unit allele) and 4- (without the four-repeat-unit allele) genotypes was identical in the two groups. Conclusion: An association between the (TTTTA)n microsatellite polymorphism in the promoter of the CYPIIA gene and the pathogenesis of OHSS could not be confirmed.
Deskriptorji     POLYCYSTIC OVARY SYNDROME
OVARIAN HYPERSTIMULATION SYNDROME
MICROSATELLITE REPEATS
POLYMORPHISM (GENETICS)
GENOTYPE
POLYMERASE CHAIN REACTION