Author/Editor		Ferk, Polonca; Geršak, Ksenija; Teran, Nataša
Title		No association between the microsatellite polymorphism (TTTTA)n in the promoter of the CYP11A gene and ovarian hyperstimulation syndrome
Type		članek
Source		J Assist Reprod Genet
Vol. and No.		Letnik 23, št. 1
Publication year		2006
Volume		str. 29-32
Language		eng
Abstract		Purpose: Women with ultrasonic evidence of polycystic ovaries are at higher risk of ovarian hyperstimulation syndrome (OHSS). We focused on investigating a possible association of the (TTTTA)n microsatellite polymorphism in the promoter of the CYP11A gene with OHSS during controlled ovarian hyperstimulation (COH). Methods: We evaluated 58 patients at high risk of OHSS (study group) and 58 control patients undergoing controlled ovarian hyperstimulation. Results: The difference in the allele distribution between both groups of patients was not statistically significant. The genotype distribution of 4+ (with at least one copy of the fourrepeat-unit allele) and 4- (without the four-repeat-unit allele) genotypes was identical in the two groups. Conclusion: An association between the (TTTTA)n microsatellite polymorphism in the promoter of the CYPIIA gene and the pathogenesis of OHSS could not be confirmed.
Descriptors		POLYCYSTIC OVARY SYNDROME OVARIAN HYPERSTIMULATION SYNDROME MICROSATELLITE REPEATS POLYMORPHISM (GENETICS) GENOTYPE POLYMERASE CHAIN REACTION