Author/Editor		Pretnar-Oblak, J; Šabovič, M; Pogačnik, T; Šebeštjen, M; Zaletel, M
Title		Flow-mediated dilatation and intima-media thickness in patients with lacunar infarctions
Type		članek
Source		Acta Neurol Scand
Vol. and No.		Letnik 113
Publication year		2006
Volume		str. 273-7
Language		eng
Abstract		Objectives - To evaluate systemic endothelial function and atherosclerotic changes in patients with lacunar infarctions (LI) we examined flow-mediated dilatation (FMD) and intima-media thickness (IMT) and compared them to patients with similar risk factors (SR) and healthy controls. Methods - FMD and IMT were investigated in patients with LI (20 patients, aged 60.9 +- 7.3 years), 21 age- and gender-matched patients with SR and 21 healthy controls. Results FMD was more impaired in patients with LI (0.4% +- 5.0%) compared to patients with SR (3.8% +- 4.8%) and healthy controls (7.9% +- 6.0%) (P <_ 0.01), whereas IMT was similarly thickened in both groups of patients. Conclusions - We found that patients with LI have a diminished FMD, but a similar IMT, compared to patients with SR. Our results reveal that for a given level of atherosclerosis patients with LI have additional endothelial impairment.
Descriptors		CEREBRAL INFARCTION CAROTID ARTERIES TUNICA INTIMA TUNICA MEDIA BRACHIAL ARTERY MIDDLE AGE AGED SEX FACTORS VASODILATION REGIONAL BLOOD FLOW