| Avtor/Urednik | Štempelj, Mateja; Ferjan, Ilonka | |
| Naslov | Kanabinoidi - njihovo delovanje in učinki | |
| Prevedeni naslov | Cannabinoids - their action and effects | |
| Tip | članek | |
| Vir | Farm Vestn | |
| Vol. in št. | Letnik 57, št. 1 | |
| Leto izdaje | 2006 | |
| Obseg | str. 30-3 | |
| Jezik | slo | |
| Abstrakt | Abstract: Cannabinoids are the active components of Cannabis saliva, their synthetic and endogenous analogues. delta9-tetrahydrocannabinol (delta9THC) is the main psychoactive component of Cannabis sativa. Its pharmacological properties are very similar to those exerted by endogenous cannabinoids. The first endocannabinoid discovered was named anandamide, with reference to its chemical structure, the amide of arachidonic acid and ethanolamine. Cannabinoids act on specific G i/0 protein-coupled C81 and CB2 receptors. The cannabinoid signaling is terminated by cellular uptake and intracellular degradative enzyme fatty acid amide hydrolase. Recent studies are focused on therapeutic uses of cannabinoids, since they exert effects in multiple conditions, including nausea and vomiting, pain loss, appetite stimulation, convulsions, autoimmune diseases and glaucoma. | |
| Izvleček | Povzetek: Med kanabinoide uvrščamo aktivne komponente konoplje, njihove sintetične in endogene analoge. Glavna psihoaktivna učinkovina konoplje je delta9-tetrahidrokanabinol (delta9-THC). Farmakološke lastnosti (delta9-THC) so zelo podobne lastnostim endogenih kanabinoidov. Najbolj znani endogeni kanabinoid, anandamid, je amid arahidonske kisline in etanolamina. Kanabinoidi delujejo preko visokoafinitetnih receptorjev CB1 in CB2, ki so sklopljeni s proteinom G i/0. Do terminacije delovanja kanabinoidov pride zaradi njihovega privzema v celico, kjer se razgradijo s pomočjo encima FAAH (fatty acid amide hydrolase). Današnje študije so usmerjene predvsem v odkrivanje terapevtske uporabnosti kanabinoidov, saj je znano, da preprečujejo slabost in bruhanje, lajšajo bolečino, povečajo apetit, delujejo proti mišičnim krčem, lajšajo simptome pri avtoimunih obolenjih in pri glavkomu. | |
| Deskriptorji | CANNABIS CANNABINOIDS |