Author/Editor		Miller, Christopher CJ; McLoughlin, Declan M; Lau, Kwok-Fai; Tennant, Maria E; Rogelj, Boris
Title		The X11 proteins, Abeta production and Alzheimer's disease
Type		članek
Source		Trends Neurosci
Vol. and No.		Letnik 29, št. 5
Publication year		2006
Volume		str. 280-5
Language		eng
Abstract		Cerebral deposition of amyloid-beta peptide (Abeta) within neuritic plaques is a hallmark pathology of Alzheimer's disease. It is now generally believed that the development of this pathology is central to the pathogenesis of Alzheimer's disease. As such, inhibiting Abeta deposition or removing Abeta deposits once they are formed represent therapeutic targets for Alzheimer's disease. Abeta is derived from a precursor, the amyloid precursor protein (APP), and APP binds to the X11 family of adaptor proteins. Studies from several laboratories have now shown that X11alpha and X11beta (the two neuronal X11s) inhibit APP processing and Abeta production. Exactly how this is achieved is not yet known but recent studies in which other X11 binding partners have been identified are beginning to reveal potential mechanisms.
Descriptors		ALZHEIMER'S DISEASE AMYLOID BETA-PROTEIN AMYLOID BETA-PROTEIN PRECURSOR PROTEIN BINDING INTRACELLULAR MEMBRANES PHOSPHOTYROSINE