Avtor/Urednik		Mirković, Tomislav
Naslov		Vpliv sorazmerne podpore predihavanju (SPP) na dihalni napor pri bolnikih v akutni dihalni stiski
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 59
Jezik		slo
Abstrakt		Objectives: Proportional assist ventilation (PAV) is a recently developed mode of synchronized partial ventilatory support, designed to reduce the inspiratory effort used to overcome elastance (ERS) and resistance (RRS) of the respiratory system by applying pressure in proportion to volume (volume assist, VA) and flow (flow assist, FA), respectively. The first aim of this study was to determine the effects of systematically varying the level of assistance provided by PAV using combined VA and FA on breathing pattern and inspiratory effort in subjects with acute respiratory failure (ARF) of various etiology. The second purpose of the study was to elucidate the difference between airway opening (pao) and tracheal (per) pressure regulated forms of PAV where VA was varied from 20 to 80% of respiratory elastance. Subjects: 7 clinical stable patients with ARF of various etiologies. Methods: Flow, volume, esophageal (pes), transdiaphragmatic (pd;), airway opening (pao) and tracheal (ptr) pressure were measured during spontaneous breathing on CPAP mode (control) and PAV trials, after the determination of patient ERS and RRS. In protocol # 1, PAV was applied using combined VA and FA at 20%, 40%, 60% and 80% of ERS and RRS, respectively. In protocol # 2 the triggering pressure for the ventilator was changed from airway opening (pao) pressure to tracheal (ptr) pressure while patients received VA (varied by 20% relative to ERS) ventilatory support only. Results: Compared to spontaneous breathing (CPAP mode) (control), already the lowest level of PAV 20% reduced (p< 0,05) the inspiratory effort, as reflected by the pressure-time integral of the inspiratory muscles (Spmus.dt) and diaphragm (Spdi.dt) mostly by reducing elastic part of effort. (Abstract truncated at 2000 characters)
Deskriptorji		RESPIRATORY DISTRESS SYNDROME VENTILATORS, MECHANICAL RESPIRATORY MECHANICS RESPIRATORY MUSCLES POSITIVE-PRESSURE RESPIRATION TRACHEA MANOMETRY ESOPHAGUS