Author/Editor		Stegnar, M; Salobir-Pajnič, B; Božič, B; Rozman, B
Title		Relationship between lupus anticoagulants and antiphospholipid antibodies detected by enzyme-linked immunosorbent assay
Type		članek
Source		Acta Pharm
Vol. and No.		Letnik 42, št. 2
Publication year		1992
Volume		str. 109-15
Language		eng
Abstract		The relationship between antibodies to cardiolipin (aCL) and phosphatidylserine (aPS) and lupus anticoagulants (LA) was studied in 20 patients with autoimmune disorders (16 had systemic lupus ecythematosus). The patients were selected according to increased aCL in their histories. aCL and/or aPS of IgG and IgM isotypes were detected with an enzyme-linked immunosorbent assay in 17/20 patients and in none of the 20 age- and sex-matched healthy controls. LA were detected and confirmed by a mixing study in 6 patients and in none of the controls. All 6 patients with LA had increased levels of aCL and/or aPS. The remaining 11 patients with aCL and/oc aPS were LA negative. The most sensitive tests for LA wece activated partial thromboplastin time with cephalin and dilute Russel viper venom time. Kaolin clotting time was positive for LA in 5 patients. The results suggested that in many patients, aCL and aPS are devoid of LA activity.
Descriptors		AUTOIMMUNE DISEASES LUPUS COAGULATION INHIBITORS ANTIBODIES, ANTICARDIOLIPIN ANTIBODIES, ANTIPHOSPHOLIPID LUPUS ERYTHEMATOSUS, SYSTEMIC IMMUNOASSAY