| Author/Editor | Gregorič, Alojz; Marčun-Varda, Nataša | |
| Title | Metabolični sindrom: zgodovina, opredelitev in klinični pomen pri otrocih | |
| Translated title | Metabolic syndrome: history, definition and clinical significance in children | |
| Type | članek | |
| Source | In: Gregorič A, editor. Metabolični sindrom pri otrocih, sodobni način življenja in imunski odziv pri otrocih, racionalna uporaba zdravil v pediatriji. Zbornik 17. srečanje pediatrov v Mariboru in 4. srečanje medicinskih sester; 2007 apr 13-14; Maribor. Maribor: Splošna bolnišnica Maribor, | |
| Publication year | 2007 | |
| Volume | str. 17-24 | |
| Language | slo | |
| Abstract | The metabolic syndrome is a constellation of risk factors of metabolic origin that are accompanied by an increased risk of atherogenic cardiovascular disease and type 2 diabetes. These risk factors are atherogenic dyslipidaemia, elevated blood pressure, elevated plasma glucose, a prothrombotic state, and a proinflammatory state. The two major underlying risk factors for the metabolic syndrome are obesity and insulin resistance; exacerbating factors are physical inactivity, advancing age, and endocrine and genetic factors. The condition is progressive, beginning in childhood, with borderline risk factors that eventually progress to categorical risk factors. In many patients, the metabolic syndrome culminates in type 2 diabetes, which further increases the risk of cardiovascular disease. In this article we attempted an overview of the history, definition and clinical significance of the metabolic syndrome in children (prevalence, aetiology, prevention and treatment). There is an urgent need for an internationally accepted definition of the metabolic syndrome in children. In the conclusion our definition is proposed. The metabolic syndrome is not just a new paediatric syndrome, but in the face of the epidemic increase in obesity in children, it rather represents a challenge for better prevention strategies. According to the Luxemburg Declaration Slovenia has successfully instigated an integrated strategy for cardiovascular prevention. |