Author/Editor		Theuer, W; Selawry, O; Karrer, K; Orel, J; Eržen, J; Hrabar, B; Klevišar, M; Debevec, M; Rott, T
Title		The impact of surgery on the multidisciplinary treatment of bronchogenic small cell carcinoma (updated review including ongoing studies)
Type		članek
Source		Med Oncol Tumor Pharmacother
Vol. and No.		Letnik 9, št. 3
Publication year		1992
Volume		str. 119-37
Language		eng
Abstract		Recent results of studies on patients with SCLC treated by surgery with curative intent followed by adjuvant chemotherapy demonstrate a definite progrress in comparison to non-surgical-treatment programs for patients with comparable stage of disease. Of 186 randomized patients enrolled for the multicenter cooperative ISC-Study I and II, 76 patients with stage pT1-3N0M0 received surgery for cure followed by chemotherapy and selective radiotherapy to the brain. The projected 4 year crude survival rate by September 1991 was 57 percent. In 27 of 43 patients with stage pT1-3N2M0, the tumors were completely resected, resulting in a 4 year survival rate of 32 percent. The survival curve for both groups of patients shows a sharp bent at 27 months postoperatively, whereafter the survival curves take a plateau-like course. These promising results were confirmed by several other groups. They are in favour of initial surgery for resectable tumors, followed by postoperative chemotherapy, while patients on preoperative chemotherapy followed by adjuvant surgery showed less favourable results.
Descriptors		CARCINOMA, BRONCHOGENIC MULTICENTER STUDIES CARCINOMA, SMALL CELL SURGERY CHEMOTHERAPY, ADJUVANT