Avtor/Urednik		Sket, D
Naslov		Thirty-five years of dopamine research
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 62, št. Suppl 1
Leto izdaje		1993
Obseg		str. 19-22
Jezik		eng
Abstrakt		The fascinating progress made in 35 year history of dopamine is reviewed in brief. The milestones of dopamine research are: determination of dopamine content in the brain structures (1957-58); discovery of low concentrations of dopamine in basal ganglia of parkinsonian patients (1960); introduction of histochemical fluorescence methods for demonstration of catecholamines in nerve cells (1962-64), followed by localization and morphological characterization of dopamine-containing nerve cells; first single unit recordings of dopamine-innervated neurons in mammalian brain (1965-67); first steps in development of dopamine-dependent behavioural models (1967-71); dopamine-stimulated adenylate cyclase assay (1971-72); introduction of radioactive ligands into studies of dopamine receptor binding in vitro (1975); classification of dopamine receptors as D1 and D2 receptors (1979); the first clinical positron emmission tomographic study of 11C-chlorpromazine binding (1979); first functionally active transplants of fetal dopamine cells in animals (1979); implantation of human fetal dopaminergic cells to parkinsonian patients, with limited clinical improvement (19881990); studies of dopamine regulation of gene expressions started in the eighties; moleculur biology of dopamine receptors (198893): cloning studies have identified two subtypes of D1, and four subtypes of D2 receptors. Progress in dopamine research improved our understanding of brain functions and opened up new therapeutic possibilities for several neurological and psychiatric illnesses.
Deskriptorji		DOPAMINE HISTORY OF MEDICINE