Author/Editor		Jensterle, Mojca; Janež, Andrej; Vrtovec, Bojan; Meden-Vrtovec, Helena; Pfeifer, Marija; Preželj, Janez; Kocjan, Tomaž
Title		Decreased androgen levels and improved menstrual pattern after angiotension II receptor antagonist Telmisartan treatment in four hypertensive patients with polycistic ovary syndrome: case series
Type		članek
Source		Croat Med J
Vol. and No.		Letnik 48
Publication year		2007
Volume		str. 864-70
Language		eng
Abstract		We describe 4 consecutive hypertensive women with polycystic ovary syndrome, classified according to the National Institute of Child Health and Human Development (NICHD) criteria, treated with telmisartan 40 mg/d for six months. Blood prcessure, menstrual pattern, body mass index (BMI), homeostasis model assessment of insulin resistance, testosterone, dehydroepiandrosterone sulfate (DHEAS), and androstenedione were recorded and measured before and after telmisartan treatment. Obese hypertensive polycystic ovary syndrome patients had a decrease in systolic blood pressure. Marked drop-off in serum androgen concentrations was observed in all four patients. Three patients improved their menstrual cyclicity. The improvements were independent of changes in weight. The reduction of androgen concentrations and improvement in menstrual pattern was achieved despite a non-significant change of fasting insulin levels in patients, who were not considered severely insulin resistant at baseline. These findings may provide a new basis for a proper choice of the antihypertensive drug in hypertensive women with polycystic ovary syndrome.
Descriptors		POLYCYSTIC OVARY SYNDROME HYPERTENSION ANGIOTENSIN II RECEPTORS, ANGIOTENSIN ANDROSTENEDIONE ADULT MENSTRUAL CYCLE BODY MASS INDEX