Avtor/Urednik		Teba, Fernando; Martin, Rocio; Gomez, Vicente; Herranz, Luis M; Santamaria, Luis
Naslov		Cell proliferation and volume-weighted mean nuclear volume in high-grade pin and adenocarcinoma, compared with normal prostate
Tip		članek
Vir		Image Anal Stereol
Vol. in št.		Letnik 26, št. 2
Leto izdaje		2007
Obseg		str. 93-9
Jezik		eng
Abstrakt		High-grade prostate intraepithelial neoplasia (PIN) is considered a precursor of prostate adenocarcinoma. The aim of this study was to quantitate the differences between basal and luminal cells of PIN in relation to mean nuclear volume (Vvnuc), and proliferating cell nuclear antigen labeling index (LIpcna), and to compare these estimates with those obtained in normal prostate and carcinoma. The epithelium of both normal and PIN specimens was segmented in basal and luminal compartments, and the Vvnuc and LIpcna measured in both strata. Vvnuc was significantly lower in normal epithelium than in both PIN and carcinoma. The Vvnuc of basal layer of PIN was significantly higher than in luminal stratum. The luminal Vvnuc was similar in both PIN and adenocarcinoma. The LIpcna was greater in PIN and adenocarcinoma than in normal glands. The LIpcna of basal cells from PIN was similar to that observed in the basal stratum from normal prostate, whereas the luminal proliferation from PIN was similar to that observed in adenocarcinoma. The similarities in nuclear size between PIN and carcinoma are according to the premalignant character of PIN. The increase of basal Vvnuc in PIN indicates that the changes heralding the progression from PIN to carcinoma are produced in this layer, whereas the nuclear features of the luminal layer are the same to those of the carcinoma. These remarks make sense in reference to the progression of malignant changes from PIN basal layer to PIN luminal layer and from this to carcinoma.
Deskriptorji		PROSTATIC INTRAEPITHELIAL NEOPLASIA ADENOCARCINOMA CELL DIVISION CELL NUCLEUS IMAGE PROCESSING, COMPUTER-ASSISTED IMMUNOHISTOCHEMISTRY CELL SIZE