Author/Editor		Perše, Matina; Horvat, Simon; Rozman, Damjana
Title		Genetski nadzor inbridiranih linij
Translated title		Genetic monitoring of inbred strains
Type		članek
Source		Acta Agriculturae Slovenica
Vol. and No.		Letnik 90, št. 2
Publication year		2007
Volume		str. 69-83
Language		slo
Abstract		With the advent of molecular genetics, inbred strains became one of the most powerful tools in biomedical research.Their applications are numerous and range from investigating basic mechanisms of genes and gene regulation to the generation of models of human diseases, which can be used for pathophysiological, biochemical, molecular and therapeutic studies. Therefore,the need for uniform and authentic animals within the genetically standardized strains is understandable and from the perspective of validity of results also necessary. The purpose of this article is to outline the potential sources of genetic variation of rodent (mainly mouse and rat) colonies and to describe the methods used to monitor or control this variation. These methodologies may be applied in both breeding centres and individual research laboratories.