| Author/Editor | Frazier, OH; Gemmato, Courtney; Myers, Timothy J; Gregorič, Igor D; Radovančević, Brane; Loyalka, Pranav; Kar, Biswajit | |
| Title | Initial clinical experience with the hheartmate II axial-flow left ventricular assist device | |
| Type | članek | |
| Source | Tex Heart Inst J | |
| Vol. and No. | Letnik 34, št. 3 | |
| Publication year | 2007 | |
| Volume | str. 275-81 | |
| Language | eng | |
| Abstract | The redesigned HeartMate ll, an axial-flow left ventricular assist device, is simpler, smalier, and easier to operate than are pulsatile pumps. These design characteristics should make the HeartMate II more reliable and durable and broaden the eligible population base. We irnplanted the HeartMate ll in 43 patients (average age, 42 yr). The indication for use was bridge-to-heart transplantation in 26 patients and destination therapy in 17. The average duration of device support was 258 days (range, 7-761 days), and cumulative duration, more than 31 patient-years. Hemodynarnic function improved in all patients during support. By 48 hours after implantation, the mean cardiac index had increased from 1.9 +- 0.27 L/(min.m2) (baseline) to 3.5 +- 0.8 L/(min.m2), and the pulmonary capillary vvedge pressure had decreased from 24.8 +- 11 rnmHg to 18.5 +- 5.3 mrnHg. Of the 4,3 patients, 35 were discharged from the hospital. Support is ongoing in 27 patients (longest duration, >700 days). Nine patients died during support. Four patients had sufficient heart recovery to undergo pump explantation. Three patients underwent transplantation. One patient underwent device replacement after the pump driveline was fractured in a skatetboarding accident; the device was removed in another patient because of a pump-pocket infection after 749 days of support. Of the 10 patients in whom the HeartMate II replaced a failed HeartMate I, 8 were discharged from the hospital. We have seen excellent results with use of the HeartMate ll. Functional status and quality of life have greatly improved in patients who survived the perioperative period. | |
| Descriptors | HEART-ASSIST DEVICES HEART VENTRICLE PREOPERATIVE CARE HEART TRANSPLANTATION |