Avtor/Urednik		Crnic-Martinovic, Marija; Grahovac, Blaženka; Vidan-Jeras, Blanka; Ristić, Smiljana; Sepčić, Juraj; Brajenović-Milić, Bojana; Peterlin, Borut; Kapović, Miljenko
Naslov		HLA class II polymorphism in autochthonous population of Gorski kotar, Croatia
Tip		članek
Vir		Coll Antropol
Vol. in št.		Letnik 31, št. 3
Leto izdaje		2007
Obseg		str. 315-9
Jezik		eng
Abstrakt		The aim of this study was to examine frequencies and haplotypic associations of HLA class II alleles in autochthonous population of Gorski kotar (Croatia). HLA-DRB1, -DQA1 and -DQB1 alleles were determined by DNA based PCR typing in 63 unrelated inhabitants from Gorski kotar whose parents and ancestors were born and lived in tested area for at least over four generations. A total of 13 HLA-DRB1, 12 DQA1 and 14 DQB1 alleles were identified. The most frequent HLA class II genes in Gorski kotar population are: HLA-DRB1*13 (af = 0.150), -DRB1*03 (af = 0.142), -DRB1*07 (af = 0.119), and -DRB1*11 (af = 0.119), HLA-DQA1*0501 (af = 0.278), -DQA1*0102 (af = 0.183), -DQA1*0201 (af = 0.127) and HLA-DQB1*0301 (af = 0.157), -DQB1*0201 (af = 0.139), -DQB1*0501 (af = 0.111). We have identified 24 HLA class II three-locus haplotypes. The most common haplotypes in Gorski kotar population are DRB1*03-DQA* 0501-DQB1*0201 (0.120), DRB1*11-DQA1*0501-DQB1*0301 (0.111) and DRB1*07-DQA1*0201-DQB1*0202 (0.094). The allelic frequencies and populations distance dendrogram revealed the closest relationships of Gorski kotar population with Slovenians, Germans, Hungarians and general Croatian population, which is the result of turbulent migrations within this microregion during history.
Deskriptorji		DNA FINGERPRINTING ADULT CROATIA GENE FREQUENCY GENES, MHC CLASS II HAPLOTYPES