Author/Editor		Kanič, Vojko
Title		Varnost statinov
Type		članek
Source		In: Hojs R, Krajnc I, Pahor A, et al, editors. Zbornik predavanj in praktikum 19. srečanje internistov in zdravnikov splošne medicine "Iz prakse za prakso"; 2008 maj 30-31; Maribor. Maribor: Univerzitetni klinični center,
Publication year		2008
Volume		str. 9-19
Language		slo
Abstract		Cardiovascular mortality is greatly reduced by statins. Most important side effects affected skeletal muscles, liver, nervous system and kidneys. Statin's blood level might be influenced by drugs metabolized through the same pathway. Side effects are increased with higher statin dose and higher statin blood levels. Side effects are not associated with intensive LDL-cholesterol lowering. Despite side effectes we could say that statins are very safe drugs.
Summary		Statini znižujejo srčno-žilno smrtnost. Najpogostejši stranski učinki statinov prizadenejo mišice in jetra, lahko pa tudi živčevje in ledvica. Pri medsebojnih učinkih zdravil na statine upoštevajmo nehoten dvig koncentracije statina v krvi zaradi slabšega presnavljanja statina. Stranski učinki statinov naraščajo z odmerkom posameznega statina in njegovo koncentracijo v krvi. Stranski učinki niso povezani s tem, za koliko znižamo LDL-holesterol v krvi. Ne glede na možne stranske učinke so statini zelo varna zdravila.
Descriptors		DRUG INTERACTIONS MUSCULAR DISEASES RHABDOMYOLYSIS