Avtor/Urednik		Sharma, Rakesh
Naslov		Enhanced electrostatic AChE activity of abnormally hydrophobic environment in Alzheimer’s plaques
Tip		članek
Vir		Inform Med Slov
Vol. in št.		Letnik 13, št. 1
Leto izdaje		2008
Obseg		str. 9-14
Jezik		eng
Abstrakt		Computational techniques based on Brownian dynamics simulation speculate the electrostatic and kinetic properties of Acetylcholinesterase (AChE) in the range of dielectric constant values 60-78. Typically the enzyme specific to Alzheimer’s Disease has specificity constant (kcat/Km) of AChE at both dielectrics constants. AChE is distributed heterogeneously within the senile plaques and neurofibrillary tangles (NFTs) of Alzheimer’s Disease (AD). The role of decreased brain AChE has been highlighted as responsible for specific Magnetic Resonance Spectroscopic pattern profiles in AD. These findings strengthen the suggestion that the altered AChE in AD may be associated with specific MR spectral peak patterns. This phenomenon may account for the reduced levels of the ACh neurotransmitter in the cerebral tissue of Alzheimer’s disease (AD) patients. These results can be useful in clinical trials on AD lesions.
Deskriptorji		ALZHEIMER'S DISEASE AMYLOID BETA-PROTEIN ACETYLCHOLINESTERASE ELECTROSTATICS MAGNETIC RESONANCE IMAGING DIFFUSION TORPEDO OSMOLAR CONCENTRATION