Author/Editor		Glaser, Marjana
Title		Transfuzijska preobremenitev z železom in njeno zdravljenje: (posvečeno prof. dr. sci. Edvardu Glaserju 1922-2007)
Translated title		Transfusional iron overload and its treatment
Type		članek
Source		In: Križman I, editor. Zbornik predavanj: interna medicina 2008: dileme in tveganja. Strokovni sestanek Združenja internistov SZD; 2008 sep 26-27; Ljubljana. Ljubljana: Združenje internistov SZD,
Publication year		2008
Volume		str. 53-7
Language		slo
Abstract		Iron overload can be a consequence of repeated blood transfusions or of increased dietary iron absorption. Deposition of excessive iron in cells results in organ dysfunction or even patients death. New methods for measuring tissue iron overload and new drugs for removing of excess iron are expected to have a major impact on management of conditions and diseases associated with iron overload. Beside mechanisms, which lead to iron overload methods for measuring of iron are represented as also chelators, which must besafe, effective and compatible with a good quality of life.
Summary		Do preobremenitve z železom (Fe) lahko pride zaradi večkratnih transfuzij eritrocitov ali povečane absorpcije Fe iz hrane. Fe se nalaga v celicah, zaradi česar pride do motenega delovanja organov in celo do smrti bolnika. Z natančnejšimi preiskavami ter novimi zdravili - helatorji, pričakujemo boljše vodenje stanj in bolezni, povezanih s preobremenitvijo. Poleg mehanizmov, ki vodijo do preobremenitve, predstavljam novejše metode za dokazovanje preobremenitve kot tudi helatorje, ki morajo biti varni, učinkoviti in primerljivi z dobro kvaliteto življenja.
Descriptors		IRON OVERLOAD BLOOD TRANSFUSION MYELODYSPLASTIC SYNDROMES DEFEROXAMINE