Avtor/Urednik		Sande-Bruinsma, Nienke; Grundmann, Hajo; Verloo, Didier; Tiemersma, Edine; Monen, Jos; Goossens, Herman; Ferech, Matus; Čižman, Milan; Mueller-Premru, Manica; Kolman, Jana
Naslov		Antimicrobial drug use and resistance in Europe
Tip		članek
Vir		Emerg Infect Dis
Vol. in št.		Letnik 14, št. 11
Leto izdaje		2008
Obseg		str. 1722-30
Jezik		eng
Abstrakt		Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000-2005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specific and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe.
Deskriptorji		AMBULATORY CARE DRUG UTILIZATION ESCHERICHIA COLI ESCHERICHIA COLI INFECTIONS EUROPE HOSPITALS LINEAR MODELS PNEUMOCOCCAL INFECTIONS PRODUCT SURVEILLANCE, POSTMARKETING RETROSPECTIVE STUDIES STREPTOCOCCUS PNEUMONIAE