Author/Editor		Leifer, Dana; Krainc, Dimitri; Yu, Yie-Teh; McDermott, John; Breitbart, Roger E; Heng, John; Neve, Rachael L; Kosofsky, Barry; Nadal-Ginard, Bernard; Lipton, Stuart A
Title		MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex
Type		članek
Source		Proc Natl Acad Sci U S A
Vol. and No.		Letnik 90, št. 4
Publication year		1993
Volume		str. 1546-50
Language		eng
Abstract		We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.
Descriptors		MULTIGENE FAMILY ANIMALS BLOTTING, NORTHERN BRAIN CEREBRAL CORTEX CLONING, MOLECULAR DNA DNA-BINDING PROTEINS FETUS GENE LIBRARY AMINO ACID SEQUENCE GENETIC VECTORS MOLECULAR SEQUENCE DATA MYOGENIC REGULATORY FACTORS ORGAN SPECIFICITY RNA RATS RECOMBINANT FUSION PROTEINS SEQUENCE HOMOLOGY, AMINO ACID TRANSCRIPTION FACTORS TRANSFECTION BETA-GALACTOSIDASE