Avtor/Urednik		Podnar, S; Vodušek, DB; Žvan, V
Naslov		Lithium and peripheral nervous system function in manic-depressive patients
Tip		članek
Vir		Acta Neurol Scand
Vol. in št.		Letnik 88, št. 6
Leto izdaje		1993
Obseg		str. 417-21
Jezik		eng
Abstrakt		INTRODUCTION--Lithium salts are widely used in treatment of affective disorders, but lithium may cause electrophysiologically detectable changes in peripheral nervous system even with lithium concentrations within recommended therapeutic limits. The risk of lithium treatment against other risks to peripheral nervous system in psychiatric patients with affective psychoses was tested in our study. MATERIAL AND METHOD--Electrophysiologic parameters of motor and sensory peripheral nerve fibre function were measured in two age-matched groups of psychiatric patients (20 lithium-treated and 20 affective psychotic patients without lithium treatment) and a group of 20 healthy age-matched volunteers. RESULTS--Lower amplitudes of M waves (p less th. 0.015) and sensory nerve action potentials (p less th. 0.020) on stimulation of the median nerve have been found in both groups of patients. On peroneal nerve stimulation lower M wave amplitudes have been found only in the group of lithium-treated patients (p less th. 0.055). No significant differences in conduction parameters of motor and sensory fibres were demonstrated. CONCLUSION--Our results demonstrate subclinical involvement of motor and sensory axons in affective-psychotic patients, which is only slightly more pronounced in lithium-treated patients. We suggest that lithium (within therapeutic plasma concentrations) is just one among the factors leading towards minor axonopathy in psychiatric patients.
Deskriptorji		BIPOLAR DISORDER LITHIUM PERIPHERAL NERVOUS SYSTEM ADULT AXONS ELECTRIC STIMULATION MEDIAN NERVE MIDDLE AGE NEURAL PATHWAYS PERIPHERAL NERVOUS SYSTEM PERONEAL NERVE