Avtor/Urednik		Reschner, Hrvoje; Milutinovič, Aleksandra; Petrovič, Danijel
Naslov		The PECAM-1 gene polymorphism - a genetic marker of myocardial infarction
Tip		članek
Vir		Cent Eur J Biol Print
Vol. in št.		Letnik 4, št. 4
Leto izdaje		2009
Obseg		str. 515-20
Jezik		eng
Abstrakt		We investigated a possible association between the C373G (Leu125VaD polymorphism in the platelet endothelial celi adhesion molecule-1 (PECAM-l) and myocardial infarction (MI) among patients with type 2 diabetes (T20M) in the Slovene population (Caucasians). The study population of this cross-sectional analysis consisted of 452 subjects with T20M lasting more than 10 years: 142 patients with MI (MI group) and 310 patients (control group) with no history of coronary diseases. There were significant differences of PECAM-1 genotype distribution in patients with MI (CC=28.2%, CG=47.2% and GG=24.6%) compared with subjects in the control group (CC= 17.1 %, CG=53.5% and GG=29.4%). The muitivariate model showed that the CC genotype of the PECAM-1 gene polymorphism (C373G) (OR=1.9, 95% CI 1.2-3.0, P=0.007) was an independent risk factor for MI. The C allele frequency was also significantly higher (P=0.oD5) in MI (51.8%) than in control subjects (41 %). In addition, our study revealed the connection between smoking habits, the duration of diabetes and the total and LOL cholesterol serum levels and MI in Slovene T20M patients.We suggest that the tested polymorphism of PECAM-l (C373G) is associated with MI. Therefore, it might be used as genetic marker of MI in T20M.
Deskriptorji		MYOCARDIAL INFARCTION POLYMORPHISM (GENETICS) ANTIGENS, CD31 DIABETES MELLITUS, NON-INSULIN-DEPENDENT GENOTYPE CROSS-SECTIONAL STUDIES