| Author/Editor | Prodan, M | |
| Title | Negenetski vidiki pogostosti idiopatske hipertrofične stenoze pilorusa | |
| Translated title | Non-genetic aspects of the incidence of idiopathic hypertrophic pyloric stenosis | |
| Type | članek | |
| Source | Zdrav Vestn | |
| Vol. and No. | Letnik 62, št. 11 | |
| Publication year | 1993 | |
| Volume | str. 523-5 | |
| Language | slo | |
| Abstract | Background. The causes of time and place variability related to the incidence of idiopathic hypertrophic pyloric stenosis (IHPS) ane not clearly understood and many hypotheses have been suggested. Regional differences have been established in a former study between the western and eastern part of Slovene territory (1979). The finding encouraged the author to search for a constant regional environmentalfactor with possible biological effects. Methods. The 10 year incidence of IHPS in Slovenia, in their 9 health districts and separately in the western and eastern part has been observed. The data of measurements of magnesium of 79 sources of drinking water have been used to compare the levels of magnesium and the incidence of IHPS in two geologically different parts of teritory. Results. During the period 1981-90 445 cases of IHPS have been registered, the mean incidence of disorder has been 1.72 per 1000 live births with nemarkable variations among 9 health districts (max. 3.12, min. 0.95 per 1000 live births). The established incidence has been in the western part 2. 03 and in the eastern 1.40 per 1000 live births. The difference i nproportions of water sources with magnesium level 15 mg or more in 1 L and those with lower values has been revealed (1.13 in the western and 1.93 in the eastern part). Conclusion. The findings suggest the hypothesis that different regional incidence of IHPS might be related to the magnesium levels in drinking water. In the presence of endogenous (hereditary) disposition the lack of magnesium together with hypergastrinemia at the end of the pregnancy might act as a triggering factor for disorder in the very young baby. | |
| Descriptors | PYLORIC STENOSIS SLOVENIA MAGNESIUM DEFICIENCY WATER POLLUTION |