| Author/Editor | Letonja, Mitja; Petrovič, Danijel | |
| Title | Kardiotoksičnost in več-organska odpoved zaradi zastrupitve z valproatom | |
| Translated title | Cardiotoxicity and multiorgan system failure caused by valporate poisoning: case report and review of the literature | |
| Type | članek | |
| Source | Acta Medico-Biotechnica | |
| Vol. and No. | Letnik 2, št. 2 | |
| Publication year | 2009 | |
| Volume | str. 52-6 | |
| Language | eng | |
| Abstract | We report the case of severe valproate intoxication presenting as multiorgan failure. This is the first report to describe severe cardiac involvement, in which a 19-year-old woman developed atrial fibrillation, diffuse T wave inversion and QT c interval prolongation with elevated specific biochemical markers of myocardial damage. After 7 days of treatment, including supportive care, gas tric lavage, activated charcoal, mannitol and hemodialysis, the patient recovered completely . After the poisoning there were no patho- logical echocardiographic changes and one month after discharge exercise stress testing did not provoke ischemia or arrhythmias. | |
| Descriptors | VALPROIC ACID MULTIPLE ORGAN FAILURE ATRIAL FIBRILLATION MYOCARDIUM GASTRIC LAVAGE ADULT CHARCOAL MANNITOL HEMODIALYSIS |