Author/Editor		Nečas, M; Vašku, V
Title		Ustekinumab in the treatment of severe rupioid psoriasis: a case report
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 19, št. 2
Publication year		2010
Volume		str. 23-7
Language		eng
Abstract		This paper describes a case of a patient with widespread rupioid psoriasis in whom ustekinumab was introduced because of a relative contraindication to conventional systemic treatment and insufficient effect of phototherapy. Improvement of his psoriasis was very rapid, with a decrease in the PASI of 63.4% (from 30.9 to 11.3) during the first 4 weeks of treatment and an additional 31.4% (from 11.3 to 1.6) within another 12 weeks. However, the patient's psoriatic arthritis has not shown much improvement so far. Treatment with ustekinumab was tolerated well by the patient without any adverse events and also significantly improved his quality of life. Ustekinumab is a welcome extension of biologicals for the treatment of psoriasis because it represents an alternative to anti-TNF alpha preparations.
Descriptors		PSORIASIS IGG ANTIBODIES, MONOCLONAL TREATMENT OUTCOME MIDDLE AGE