Avtor/Urednik		Čižman, M
Naslov		Klinična uporaba kombinacije antibiotikov
Prevedeni naslov		Clinical use of antibiotic combinations
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 63, št. 4
Leto izdaje		1994
Obseg		str. 221-6
Jezik		slo
Abstrakt		Background. The article focuses on those combinations that are of clinical use. Conclusions. Combinations of antimicrobial agents are commonly used, most often in immunocompromised and in intensive care unit patients. It seems likely, however that the combination therapy is employed more frequently than warranted. The most prominent reasons are to increase the antimicrobial spectrum, to treat polymicrobial infections, to enhance killing or inhibition (synergism), to reduce the potential for developing resistance and less commonly to decrease the dosage of potentially toxic antibiotics. However antibiotic combinations can result in antagonismus, increased side effects, costs and other undesirable effects.
Deskriptorji		BACTERIAL INFECTIONS ANTIBIOTICS, COMBINED DRUG THERAPY, COMBINATION DRUG SYNERGISM DRUG ANTAGONISM DRUG INTERACTIONS