Author/Editor		Dolenc-Stražar, Zvezdana; Cerar, Anton
Title		Patologija kronične vnetne črevesne bolezni
Translated title		Pathology of the inflammatory bowel disease
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 49, št. 4
Publication year		2010
Volume		str. 445-60
Language		slo
Abstract		The article shows a histopathological review of inflammatory bowel disease (IBD) and the associated neoplasia. Its etiology is stilI not well defined and it involves genetic susceptibility, abnormalities in the gut epithelium, gut bacteria, and dysregulation ofhost's immune response. Its incidence is higher in the developed world and is stil! growing. Most cases of IBD comprise ulcerative colitis and Crohn's disease, and the remaining 5-15% involve indeterminate colitis. In the differential diagnosis, colitis induced by nonsteroidal antiinflammatory drugs, ischemic colitis, radiation colitis, infectious colitis, graft versus host disease, and colitis associated with diverticular disease need to be excluded. Patients with long-term disease have an increased risk of developing neoplasia and after 10 years with this disease the carcinoma risk increases by 1-2% each year.
Descriptors		INFLAMMATORY BOWEL DISEASES COLITIS, ULCERATIVE CROHN DISEASE INTESTINAL NEOPLASMS