Avtor/Urednik		Bajuk-Studen, Katica; Šebeštjen, Miran; Pfeifer, Marija; Preželj, Janez
Naslov		Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndrome
Tip		članek
Vir		Eur J Endocrinol
Vol. in št.		Letnik 164, št. 3
Leto izdaje		2011
Obseg		str. 389-95
Jezik		eng
Abstrakt		Objective Accumulating evidence connects polycystic ovary syndrome (PCOS) with increased risk of cardiovascular disease. Endothelial dysfunction is present in PCOS and represents an early, reversible marker of cardiovascular damage. As androgens and renin-angiotensin-aldosterone system are implicated in the atherogenesis process of PCOS, we tested the hypothesis that treatment with spironolactone, an androgen and mineralocorticoid receptor blocking drug, might reverse endothelial dysfunction in PCOS. Patients A total of 30 non-obese PCOS patients, compared with 20 body mass index matched control subjects, were evaluated. PCOS patients were given spironolactone 100 mg daily in 21-day long intervals followed by a 7-day pause, for 6 months. Measurements Flow-mediated dilatation (FMD), glyceryl trinitrate-induced dilatation, free testosterone, androstenedione, DHEA-sulfate, total, low-density lipoprotein (LDL)-, high-density lipoprotein-cholesterol, and triglycerides were determined at baseline and after 6 months. Results Results are expressed as median (25-75th percentile). At baseline, FMD was significantly lower in PCOS patients than in controls: 6.0 (0.0-11.7) vs 10.2 (6.8-15.9) %, P=0.018. This difference disappeared after 6 months of spironolactone treatment, as FMD in PCOS patients significantly increased to 8.3 (5.7-10.3) %, P=0.034, and was no longer different from controls. In PCOS patients, serum androgen levels did not change during treatment, while total and LDL-cholesterol decreased significantly from 4.8 (4.1-5.1) mmol/l to 4.4 (3.9-4.8) mmol/l and from 2.5 (2.1-3.1) to 2.2. (2.1-2.5) mmol/l, P<0.05 and P<0.05 respectively. Conclusion Treatment with spironolactone normalized endothelial function and improved cholesterol levels in non-obese PCOS patients.
Deskriptorji		POLYCYSTIC OVARY SYNDROME ENDOTHELIUM, VASCULAR SPIRONOLACTONE NITROGLYCERIN BODY MASS INDEX VASODILATION TESTOSTERONE ANDROSTENEDIONE LIPOPROTEIN-X DEHYDROEPIANDROSTERONE SULFATE