Avtor/Urednik		Hudler, Petra
Naslov		Genetic aspects of gastric cancer instability
Tip		članek
Vir		The scientific world journal
Vol. in št.		Letnik 2012
Leto izdaje		2012
Obseg		str. 1-10, 761909
Jezik		eng
Abstrakt		Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous disease, and although much has been learned about the different genetic changes that eventually lead to its development, the detailed mechanisms still remain unclear. Malignant transformation of gastric cells is the consequence of a multistep process involving different genetic and epigenetic changes in numerous genes in combination with host genetic background and environmental factors. The majority of gastric adenocarcinomas are characterized by genetic instability, either microsatellite instability (MSI) or chromosomal instability (CIN). It is believed that chromosome destabilizations occur early in tumour progression. This paper summarizes the most common genetic alterations leading to instability in sporadic gastric cancers and its consequences.
Deskriptorji		STOMACH NEOPLASMS ADENOCARCINOMA MICROSATELLITE REPEATS CHROMOSOME ABNORMALITIES DNA DAMAGE HELICOBACTER PYLORI SIGNAL TRANSDUCTION