Avtor/Urednik		Genden, Eric M; Sambur, Ian M; Almeida, John R; Strojan, primož
Naslov		Human papillomavirus and oropharyngeal squamous cell carcinoma ewhat the clinician should know
Tip		članek
Vir		Eur Arch Oto-Rhino-Laryngol
Vol. in št.		Letnik 270, št. 2
Leto izdaje		2013
Obseg		str. 406-16
Jezik		eng
Abstrakt		The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising in contrast to the decreasing incidence of carcinomas arising in other subsites of the head and neck. The human papillomavirus (HPV) infection has played an increasing role in these epidemiological changes and as the etiology for a significant fraction of head and neck squamous cell carcinomas, OPSCC in particular. Most importantly, many retrospective studies have shown that the prognosis differs significantly between patients with HPV-associated tumors and non-HPV associated tumors. Thus, questions arise on the choices of treatment for patients based on HPV status and the consequences of therapy. Given the recognized relevance of HPV status in OPSCC, many new questions concerning the biology, treatment, and prevention of HPV infection arise. This review is intended to highlight some of the major issues and frequently asked questions relevant for the clinician dealing with patients with OPSCC.