Avtor/Urednik		Perše, Martina
Naslov		Oxidative stress in the pathogenesis of colorectal cancer
Tip		članek
Vol. in št.		Letnik 2013
Leto izdaje		2013
ISSN		2314-6141 - BioMed research international
Jezik		eng
Abstrakt		There is a growing support for the concept that reactive oxygen species,which are known to be implicated in a range of diseases, may be important progenitors in carcinogenesis, including colorectal cancer (CRC). CRCis one of themost common cancersworldwide, with the highest incidence rates in western countries. Sporadic human CRC may be attributable to various environmental and lifestyle factors, such as dietary habits, obesity, and physical inactivity. In the last decades, association between oxidative stress and CRC has been intensively studied. Recently, numerous genetic and lifestyle factors that can affect an individuals ability to respond to oxidative stress have been identified. The aim of this paper is to review evidence linking oxidative stress to CRC and to provide essential background information for accurate interpretation of future research on oxidative stress and CRC risk. Brief introduction of different endogenous and exogenous factors that may influence oxidative status and modulate the ability of gut epithelial cells to cope with damaging metabolic challenges is also provided.
Proste vsebinske oznake		reactive oxygen species colorectal cancer epithelial cells reaktivne kisikove spojine kolorektalni rak epitelijske celice