Avtor/Urednik | Battelino, Nina; Pokorn, Marko; Švent-Kučina, Nataša; Križan-Hergouth, Veronika; Novljan, Gregor | |
Naslov | Fulminant peritonitis presumably caused by panton-valentine leukocidin-positive staphylococcus aureus in a girl on peritoneal dialysis | |
Tip | članek | |
Vir | In: Special issue : contributions from the 5th Slovenian Congress of Nephrology with international participation [S. l.] : International Society for Apheresis | |
Leto izdaje | 2013 | |
Obseg | str. 431-437 | |
Jezik | eng | |
Abstrakt | Peritonitis is a significant complication of peritoneal dialysis (PD) and the most common cause of technique failure. Panton-Valentine leukocidin (PVL), a cytotoxin produced by certain strains of Staphylococcus aureus (SA), causes destruction of neutrophils, and is associated with severe invasive infections.We present a 2.5-year-old girl on PD, who presented suddenly with an unusually fulminant and protracted course of peritonitis. Only a few hours after the onset of clinical signs, septic shock developed. PVLpositive methicillin-sensitive SA (MSSA) was grown and initial empiric antibiotic treatment changed to flucloxacillin and rifampicin in order to minimize toxin production. In spite of adequate antibiotic treatment and PD-catheter removal, recovery was slow. No PD-related peritonitis in children associated with PVL-producing strains have been reported so far and no specific recommendation exists for treatment.We speculate that PVL contributed to the severity and outcome of peritonitis in our patient. KeyWords: Children, Panton-Valentine leukocidin, Peritoneal dialysis, Peritonitis, Staphylococcus aureus. | |
Proste vsebinske oznake | peritonitis peritoneal dialysis staphylococcus aureus |